The Expression And Function Of Thioredoxin-binding Protein2/Vitamin D Up Regulated1(VDUP1) In Peripheral Bloodeosinophils From Patients Of Asthma

BackgroundAs a common chronic disease, the incidence of asthma increase year after year. It is fundamental that investigate the molecular mechanism of asthma which including genetic factors, environment, immunity, the inflammation and reconstruction of bronchus for controlling asthma. It has been approved that asthma is a polygene disease influenced by genetic variants and environment. Some controversy exist in the mechanism of asthma, including the role of eosinophils(EOS) in asthma.EOS is one of the effect cells in asthma. It has been proved that APC present antigen to surface of cell and result in the differentiation of Th2 that secrete cytokines, such as IL-4, IL-5 and IL-13. These cytokines facilitate CD34+ hematopoietic cell differentiate to EOS lineage in marrow. And then, the cells migrate from marrow to blood vessel induced by IL-5. VCAM-1, induced by IL-4 and IL-13 in endothelium, which band with receptor such as VLA-4 on the surface of EOS. So EOS can traverse vessel wall easily and recruit to the position of inflammation. The activated EOS act on all kinds of cells, such as fibroblast, muscle cells, epithelium, and secrete...