Clinical Investigation Of Renal Function Changes After Heart Valve Replacement

Background: Although the technic of cardiopulmonary bypass(CPB) and operation have been improved with betterments of anaesthesia and management of period around surgery reduce the injury of renal function, the renal dysfunction is also the frequent combine disease after CPB. It was reported that the ratio of renal dysfunction is from 7% to 40%,and the ratio of acute renal failure(ARF) is from 1% to 10%.But when ARF happens, it can make the mortality rate be from 45% to 90%. So realize the influence factor of ARF and forepart diagnosis then treat it should be very important. Glomerular filtration rate(GFR) is a very important guideline to appraise renal function. There are some in common use methods to measure GFR, such as inulin extraction ratio, chromium ethylenediamine tetracetic acid( ⁵¹Cr-EDTA), diethylenetriamine pentacetic acid( ⁹⁹mTc- DTPA), iothalamate, Ominipaque Solution, et al. These methods are cumbersome and time-consuming, and not generally applicated in clinical assessment. At present, endogenous markers such as serum creatinine and creatinine clearance(CrCl) are extensively used to evaluate renal function. The ideal marker of GFR should be an endogenous molecule that is produced at a constant rate and is cleared solely by the kidneys via free glomerular filtration, without being either secreted by tubular cells or reabsorbed into peritubular circulation. Serum creatinine is consistent with the first demand, and its...