Myocardial Remodeling And Ventricular Functional Impairing And Intervention With Perindopril Following Rat Coronary Microembolization

BackgroundsCoronary micro-embolization (CME) is a common complication of coronary artery disease especially in acute coronary syndrome. CME is frequently followed by spontaneous coronary plaque rupture, squeezed plaque rupture by mechanical intervention of PCI, incomplete thrombolysis during fibrinolytic therapy, and several vasoactive substances such as TNF-α, epinepherin may also involved in micro-circulation dysfunction after CME. CME severely and equally affects both the ventricular function and the clinical prognosis and has been proven to be more difficult in the management, by comparing the treatment of acute coronary syndrome with larger conduct coronary artery occlusion. Until now, most studies, however, more emphases the acute management of CME, and the chronic adverse impaction of CME and its efficacious intervention remain unclear, and accordingly need a further study.ObjectivesThis study was designed to explore the evidences of myocardial and ventricular remodeling and ventricular function impairement following CME, to investigate possible mechanisms involved in myocardial and ventricular remodeling, and to observe whether Perindopril, an angiotantsion-converting enzyme inhibitor, was able to regress or diminish ventricular remodeling and...