| BackgroundDiabetes mellitus is a kind of metabolism syndrom charactered by long-term high glucose,complicated with multiple-organ chronic lesion on eyes, the kidney, the nerve and the heart et.al. In 1972, Rubier discovered a kind of specific cardiomyopathy among some diabetic patients with obsolete coronary atherosclerosis. In 1974, Hamby proposed a concept about diabetic myocardiopthy through further patho-investigation for the first time, and also think that DCM has the relationship with metabolic disturbance of DM.The pathogenesis of diabetic cardiomyopathy hasn't been elucidated exactly so far, including the disequilibrium of intracellular Ca2+ homeostasis, oxidative stress, cytokines and ECM, abnormal metabolism of free fatty acids. In the 64th ADA conference, a new theory — unifying mechanism, was put forword by Professor Michael A. Brownlee,who proposed that the four traditional pathyways are the result of the overproduct of superoxide radical produced in the cell mitochondrial,in other words, that is oxidative stress. Hyperglycemia results in the overproduction of superoxide, makes mutations in mitochondrial DNA and activates the poly-ADP-ribosyl-pclymerase. Then the activity of GAPDH decreased, and the glycometabolism products can't enter the normal aerobic oxidative pathway, all those can increased advanced glycation end-product(AGE) formation; activation of protein kinase C (PKC) isoforms; and increased hexosamine pathway flux and result in a...
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