Induction Of Plaque Erosion And Thrombosis In An Atherosclerotic Rabbit Model

ObjectiveAcute coronary syndrome (ACS) and cardiac ischemic sudden death are life-threatening with a vulnerable plaque as part of the pathology. Plaque rupture and erosion are both important subtypes of vulnerable plaque. Compared with plaque rupture, plaque erosion has been less learned, and its main characteristics are following: (1) no rupture in the fibrous cap; (2) endothelial denudation at the plaque/thrombus interface; (3) deep lipid pools (necrotic cores are uncommon, when present, the necrotic core does not communicate with the luminal thrombus); and (4) an abundance of smooth muscle cells and proteoglycans.Plaque erosion is responsible for 25%-40% of acute coronary thrombotic events, and is more common in relatively younger sudden death, including men < 50 years of age and premenopausal women. Due to the risk factors such as smoking, obesity, less exercise, and working stress, the rate of cardiac ischemic sudden death and ACS has been rising, and the average age of onset is decreasing. There is a critical need for further study of plaque erosion. Thus far, little has be known about the mechanism that causes erosion. This is partly due to the lack of proper animal models and autopsy founding does not reflect situation in vivo. Furthermore, it is difficult to carry out clinical research because plaque erosion is most common in cases of sudden death. Additionally, specific equipment is needed for the diagnosis, and diagnosis standards...