Study Of The Ginkgolide B Improve Motor Capacity And Inhabit Apoptosis After Spinal Cord Injury In Rats

Spinal cord injury (SCI) interrupts conduction of nerve impulses, leading to neurological dysfunction, and the treat is hotspot and difficulty all over the word. Recent the incidence rate of spinal cord injury increase year by year and have no effective way to cure. How to adopt measures after SCI to protect spinal cord tissue effectly and protect neurons, decrease its death, promote restoration of structure and function will have great benefits to medical and society.The final consequence of spinal cord injury was determined by primary injury and secondary injury. Primary injury to the spinal cord immediately disrupts cell membranes, destroys myelin and axons in the longitudinal tracts, and damages microvessels, triggering devastating secondary injury process with the release of various deleterious factors. Multiple cellular and molecular mechanisms of the secondary injury process cause neurodegeneration, working through complex cascades to spread neurodegeneration beyond the site of primary injury. Because of primary injury is inconvertible, the clinical treatment strategies mainly focused on to control secondary injury mediators of SCI. These mediators including free radical, nitrogen monoxidum (NO), platelet activating factor (PAF), excitatory amino acids(EAA), dielectric changes, energy metabolism disorder, lipid peroxidize and apoptosis etc. Recent study deems that apoptosis as an activated death takes an important role in secondary SCI as well as passive cells death caused by mechanical trauma and inflammation and that demyelination following SCI is due to apoptosis. Therefore adopt effective treatment to protect injury spinal cord, retrieve never cells and increase its survival, promote axonal restore and relegation, may can improve recover the function of injury spinal cord.Ginkgolide B (GB) is one of compounds isolated from Chinese herb Ginkgo biloba L, and has great antagonistic effect on platelet activating factor (PAF), protect neurons against glutamate neurotoxicity, and are effective in treating patients with...