The Relationship Of MRI Features And Vascularity And The Expression Of Ki-67 In Intracranial Meningiomas

Objective: To investigate the relationship of MRI features and the expression of vascular endothelial growth factor (VEGF) and Ki-67 and microvessel density ( MVD ) inintracranial meningiomas.Methods: 57 meningioma specimen were collected for the retrospective analysis, which were testified by MRI imaging, and proved by operation and pathology. The expression of VEGF and Ki-67 was detected by immunohistochemical techniques, and the microvessel was immunostained by use of CD34 mono-antibody, then MVD was messured to show tumor vascularization. The SIEMENS 0.2 common conduct Magnetom openviva was used, the transversal and sagittal orientation have been scanned as routine patterns, and the coronal scan were performed in partial cases. All patients were scanned with T|-weighted imaging (TR/TE=420.0/15.0 ms), T₂-weighted imaging (TR/TE=6000.0～6285.0/134.0 ms) and contrast-enhanced T₁-weighted imaging, which was obtained after injecting Gd-DTPA(0.1 mmol/kg) through cubital vein. We measured the tumor size, contour, interface between tumor and normal brain tissue, signal intensity and homogeneity, peritumoral edema, signal homogeneity in contrast-enhanced T₁WI and invasion of adjacent structures in MR imaging, then analysed the relationships of the expression of VEGF and Ki-67, MVD, MRI features and histological grades. Results: The expression of VEGF and MVD were different in the different size and contour of meningiomas ( P<0.05 ) ; There were significant differences about the expression of VEGF and MVD between the clear interface tumors and unclear ones...