| Objective: The anaphase promoting complex(APC) promotes the degradation of mitotic cyclins as well as other substrates involved in sister chromatid adhesion. This study was carried out to examine the relationship between the APC expression and the clinicopathological variables, in an attempt to determine the role of the APC in the colorectal cancer and to evaluate the possibility of an aberrant APC function in surgically resected adenocarcinoma of colorectum. Methods: Immunohistochemical staining was performed for APC And Ki-67 in 103 cases of Adenocarcinoma and 11 cases of mucinous adenocacarinoma of colorectum, using the avidin-biotin-peroxidase method. Results: In colon cancer, the 44 cases (67.7%) showed immunopositive reactions for APC. The APC posivity in histologic grades 1, 2, and 3 were 16 cases (36.3%), 15 cases (34%), and 13 cases (29.7%), respectively. In the rectal cancer, the 38 cases (77.6%) showed immunopositive reactions for APC. The APC posivity in histologic grades 1, 2, and 3 were 13 cases (34.2%), 12 cases (31.6 %), and 13 cases (34.2%), respectively. The mean value of the Ki-67 labeling index was in the APC-positive group and in the APC-negative group(P=0.028). The APC expression was not statistically correlated with clinical location, age, T stage, TNM, and differentiation. Conclusion: The APC may have an aberrant function, such as a change in its role in controlling the cell cycle, and might be associated with the invasiveness and proliferation of tumor cells.
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