Human Papillomavirus Genotyping By HPV DNA Chip In Cervical Squamous Cell Carcinoma

Objective: To exploe the human papillomavirus(HPV) genotyping in cervical squamous cell carcinoma(SCC).Methods: The HPV DNA chip harbors 27 HPV probes was used to investigate the distribution of HPV genotypes in 47 cases of cervical SCC. Results: The prevalence of HPV in cervical SCC was 78.72%, HPV-16 was the most frequent type (85.29%) in single HPV infection, multiple HPV infection were detected in 3 cases(2 double, 1 triple).Coclution: HPV Infection was closely related to SCC, HPV-16 was the most frequent type in SCC. HBV DNA Chip can simultaneously detect different HPV genotypes and multiple infection, and might be beneficial for prevention and management of SCC.