Prostate Epithelium Potassium Ion Channel Expression And It's Function In The Patients With Chronic Prostatitis

Objective To investigate the function of Kv1.3 potassium ion channel in the pathogenesis of chronic prostatitis.Methods 128 prostate specimens were collected including 123 post operation of human benign prostate hyperplasia which all came from our hospital during the time of 2000.1 - 2003.12, 55-83 years old; 2 of corpse bodys for renal transplantation, 19 and 22 years old respectively; and 3 of post total cystectomy, 48, 49 and 51 years old respectively. By using the light microscopy, the 128 hematoxylin-eosin stained slides were observed. Kv1.3 potassium ion channel expression in prostatic epithelia was detected in the selected tissues of 75 human benign prostatic hyperplasia specimens after operation, 55-78 years old, among of them with and without chronic inflammation was 42 and 33 respectively, by using the method of SP immunohistochemistry.Results Obvious nodular inflammatory cells infiltration in the peripheral zones, transitional zones and periurethral gland regions but not in the central zones were observed in 67 among all the 128 prostate specimens, which accounding for the pecentage of 52.3. For nodular inflammatory cells infiltration 3 were observed in the 5 non-hyperplasia of prostate, and 64 were observed in the 123 hyperplasia of prostate. There was no statistic differences between the two groups, x~2 = 0.122, P > 0.05. For Kv1.3 21 and 14 strong and moderate immunostaining were observed in prostatic epithelia in the inflammation and noninflammation group, and 12 and 28 displayed low staining respectively. There was statistic differences between the two groups, x~2 = 6.8182, P<0.05.