The Levels Of 15 SLE Associated Autoantibodies In Serum And Their Clinical Values

Objective To explore the levels of 15 SLE-associated autoantibodies in serum samples from 71 healthy individuals and 20 new SLE patients, and to discuss their clinical values for SLE.Methods 15 SLE-associated autoantibodies were detected in serum of 71 healthy individuals and 20 new SLE patients by ELISA methods. General information and clinical information were collected. The 32 controls were selected from the healthy individuals. The levels of each autoantibody in each group and their correlations were described, the clinical roles of the autoantibodies were analysed, while their roles for SLE diagnosis were discussed.Results In the normal group, at least one autoantibodies were detected positive in 10 individuals(14.1%), the positive numbers of anti-ssDNA and anti-β₂GP1 were the highest. The OD₄₅₀ of anti-MPO in males were higher than that in females; significant differences were found for AHA and other 5 autoantibodies among different age groups. Positive rank correlation were found between 24 autoantibodies pairs, and negative rank correlation between 3. In the case group, 0 to 8 auantibodies were detected positive for a same patient, 4 auantibodies were negative. The anti-ssDNA's positive rate (85%) was the highest, there were positive rank correlation between the autoantibodies in 19 pairs. Positive rank correlation were found between the number of positive autoantibodies and disease duration. There were significant associations of rRNP with photaesthesia and of AHA with nephritis. When the early appearance of clinical manifestation was analysed, there were significant associations of AnuA with discoid erythema and of anti-U₁RNP with photaesthesia and of anti-Sm with nephritis and of anti-β₂GP1 with other clinical...