Correlation Between Three-dimensional Ultrasound Vascularity Volume Index And Pathologic Microvessel Density Of Breast

ObjectiveAngiogenesis is the formation of new capillaries from the existing vascular network and is essential for all tumor growth and dissemination. Some studies have shown that intratumoral microvessel density (MVD) is an important prognostic marker of survival in breast cancer. Although there have been reports on the correlation between Doppler sonography and pathologic MVD, but there are no studies in three-dimensional ultrasound vascularity volume index(VVI).The aim of this study was to determine the relationship between three-dimensional ultrasound VVI or two dimensional color pixel density(CPD) and pathologic microvessel density(MVD) of breast masses.Methods42 patients with breast masses were examined by three-dimensional ultrasound(3D-US), calculate the three dimensional VVI of breast masses. Computer assisted analyzed two dimensional color pixel density of breast masses. MVD was calculated in surgical specimens after immunohistochemical staining using anti-factor CD34.Results3D-US provided a clear stereoscopic view of breast masses. These studies showed a significant linear correlation between CPD/VVI and MVD(r_CPD=0.4318, P=0.005;...