Expression And Implication Of Survivin And Its Correlation With C-myc In Hepatocellular Carcinoma

Part I Expression and clinical implication of c-myc in hepatocellular carcinomasObjective To investigate the expression of c-myc and it's relationship with the clinical feature of hepatocellular carcinoma (HCC).Methods In 59 specimens of HCC tissues and noncancerous adjacent liver tissues, the expression of c-myc was detected by using immunhischemistry.Results Of the 35(59.3%)cases of HCC expression c-myc in 59 cases of HCC, the expression rate of c-myc was higher than that of the adjacent noncancerous liver and the normal liver groups(P<0.05). The expression of c-myc in HCC had no association with the patient age and sexuality, the tumor size and differentiated level of HCC (P>0.05), but with the metastasis of HCC (P<0.05). By Kaplan-Meier Log-Rank estimation, it was found the positive expression of c-myc was associated with poorer survival compared with the negative expression (P=0.0039).Conclusion c-myc probably promotes the metastasis of HCC, c-myc is demonstrated as the prognostic factor for patients undergoing hepatic resection.