| Objective: 1.To evaluate the levels of FFN and IL-6 in cervicovaginal secretions of women with threatened preterm labor and with normal course pregnancy and their correlations with the outcomes of pregnancy; 2.To observe whether combined detction of FFN and IL-6 can elevate the accuracy in predicting preterm delivery and to explore new predictive methods for preterm delivery.Methods: Samples of cervicovaginal secretion were obtained from 43 patients with the diagnosis of threatened preterm labor (study group) and 41 pregnant women between the same gestational weeks(control group) ,FFN and IL-6 were measured by ELISA. Results: (1) FFN and IL-6 levels of the study group were higher than those of the control group , p<0.05; their levels of the group with preterm parturition were higher than those of the group with term parturition , p<0.05; FFN level was positively correlated with IL-6 level, r=0.657 ,p<0.05.(2) For FFN or IL-6 in predicting preterm delivery ,the sensitivity, specificity ,positive predictive value and negative predictive value were 80.00% vs 63.33% ,79.63 % vs85.19% ,68.57% vs 70.37% and 87.76%.vs 80.70% respectively; in predicting delivery within one week, the sensitivity, specificity ,positive predictive value and negative predictive value were 90.00% vs 85.00%, 74.43 vs 84.38%,51.43% vs 62.96%,and 95.92%.vs 94.74% respectively;combinating FFN with IL-6 in predicting preterm delivery or delivery within one week, the parallel sensitivity were 92.67% vs 98.50%, the parallel specificity were 67.84% vs 61.96% .the parallel coupling sensitivity were 50.66% vs 76.50%, the parallel coupling specificity were 96.98% vs 95.85%.(3)Both FFN and IL-6 were negatively correlated with the sampling-to-delivery intervals, r=-0.688 vs–0.552, p<0.05 (4) The delivery gestational... |
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