Resach On TNF-a And The Chronic Serious Hepatitis B Relations

The Serious hepatitis is the liver cell which causes by each kind of cause of isease widespread and the massive necroses, then the liver function serious harm or the liver function failure are the result of the clinical synthesis drafts, treatment difficulty big, the condition seriously injured, the development is rapid, the case fatality rate reaches as high as above 80%. The domestic heavy hepatitis mainly is the hepatitis B ccounts for 81.82%.Among at present, (TNF) as the core inflammation germ cell factor network sends the hepatitis B liver necrosis mechanism take the tumor necrosis factor to receive takes, TNF alpha is most important by TNF. The tumor necrosis factor is the participation many kinds of physiologies and the immunity process important cell factor, has the widespread biology activeness [1]. TNF alpha expresses the MHC-1 kind of antigen through promotion virus specificity CTL but to strengthen CTL to the viral infection liver cell damage function; Under may in factor and so on endotoxin stimulate, and so on produces IL-1, IL- 6, IL-8, the thrombus element, the blood platelet activation factor through the induction uninuclear cell and the blood vessel e-ndothelial cell (PAF) the white blood cell three alkene and TNF alpha and so on own inflammation factor and so on cell factor and NO, each other constitutes a unique cell factor network, TNF alpha key role, other medium display coordination, the ssistance and the enhancement function, participate in the liver cell together the damage, causes the liver cell Continues sends harm.Recently studies discovered TNF alpha has the multi- state properties but these multi- state properties influence to copy the level thus to affect TNF alpha in the blood...