The Significance Of The Expression Of EphB2 In HCC And Its Correlation With MVD

Hepatic cellular carcinoma (HCC) is one of the most common cancers of the world which has high disease rate and mortality. In our country HCC is the second reason of death for malignant tumors. It was proved that invasion and metastasis was the main reason for the bad endings of HCC patients. So the predication and treatment of invasion and metastasis become one of the key points for the research of HCC. EphB2 belongs to Eph family, the largest subgroup of receptor tyrosine kinases family (RTKs). Receptor tyrosine kinases family is the key part of signal transmission which participates in cell forming control, cell growth, differentiation, migration, embryonic blood vessel forming and oncogenesis. Eph family members are widely expressed in all normal adult organs and tissues and have high level expression in many tumors. As a member of Eph family, EphB2 has high level expression in many tumors and has a close correlation with oncogenesis and its bad prognosis. In recent research people found that the expression of EphB2 can promote the invasion, metastasis and angiogenesis of some malignant tumors. There is few research concentrate on the expression of EphB2 in HCC. The research about the expression of EphB2 in HCC and its relationship with clincopathology, tumor angiogenesis has not been reported. To research the expression of EphB2 may contribute to know the...