The Expression Of Osteopontin, Matrix Metalloproteinases-10 In Renal Cell Carcinoma And The Relationship Between Them

Background and ObjectiveRenal carcinoma, also called renal cell carcinoma (RCC), is one of the most common malignant renal parenchyma tumors. The incidence rate of RCC is only less than bladder cancer in uroepithelium malignant tumor. The etiopathogenisis of renal carcinoma is unknown yet, it maybe related with many factors. Invasion and metabasis are the character and symbol of malignant tumor, and they are also the main reasons of the defeat of treatment and the death of patients in advanced stage of cancer. So founding cancer earlier and stoping the invasion and metabasis of cancer are two important ways of cancer treatment. Recently, the development of cell biology and molecular biology revealed that many oncogenes and their product.As an integrin-binding protein, Osteopontin (OPN) was considered to be involved in a variety of physiological cellular functions. It has been shown to play an important role in tumorigenesis, tumor invasion, and metastasis. OPN was implicated in malignancy in studies and from the observation that tumor cells with high metastatic potential had increased OPN expression. Now, OPN is a new index of tumor.Matrix metalloproteinase (MMPs), are a family of at least 24 structurally related zinc-dependent endopeptidases central to tumor invasion, metastasis, angiogenesis, and malignant cell proliferation. Multiple proteolytic enzymes have been demonstrated to be...