Expression Of COX-2 And HER-2/neu In Ovarian Epithelial Cancer And Its Clinical Significance

Ovarian cancer is the most common gynecological malignancy, as well as the leading cause of death from gynecological cancers . The survival rate of patients detected on early stage is above 90%. Due to the often asympomatic of the early stage of the this disease ,the 5-year survival rate with advanced epithelial ovarian cancer is lower than 25%. Despite the survival of patients with advanced epithelial ovarian cancer has been improved with the advances in surgery and more effective chemotherapy, chemotherapy failure and progression of disease still occur with some advanced epithelial ovarian cancer unclearly. Finding new and effective therapy is still the focus of the research on the ovarian cancer .Discovery of various makers on tumor provide new methods for the diagnose of tumor. Cyclooxygenase-2(COX-2) is an important rate-limiting enzyme for the synthesize of prostaglandins, Two COX isoforms have been characterized,COX-1 and COX-2: COX-1 is constitutively expressed in almost all tissues where it serves homeostatic functions, and COX-2 expression is highly inducible, usually cannot be detected in physiological situation .Recent research found COX-2 overexpression is associated with cancer, and animal tests have proved the inhibitator of COX-2 can reduce the death rate and slow down the growth of tumor in colorectal cancer .so it is supposed that COX-2 overexpression is associated with the development of...