| Coronary heart disease is a progressive disease that results in a continuum of clinical manifestations, ranging from asymptomatic atherosclerosis and stable angina pectoris (SAP), to acute coronary syndrome (ACS) which includes unstable angina pectoris (UAP), acute myocardial infarction (AMI) and sudden death (SD). All these diseases share the common pathophysiology processes characterized by coronary plaque disruption with superimposed thrombus formation. It has been proved that platelets play an important role in the pathogenesis of ACS. Researches have found that soluble P-selectin (sP-selectin) is a cellular adhesion molecule which plays an important role in mediating the interaction of activated endothelial cells or platelets with leukocytes during inflammatory response and thrombus formation. It is also a non invasive marker of coronary plaque destabilization which reflects the damage of endothelial cell and platelet activation.Recent evidence has demonstrated that atherosclerosis is not simply a disease of lipid deposition. Inflammation plays a major role in the initiation, progression, and destabilization of plaque. High-sensitivity C-reactive protein (hs-CRP) is a circulating acute-phase reactant that reflects active systemic inflammation. Large prospective trials have shown hs-CRP to be a strong predictor of future cardiovascular events. Increased hs-CRP concentration is in fact associated with higher cardiovascular events in individuals with and without clinical evidence of atherosclerotic disease. The relative risk associated with hs-CRP is independent of other cardiovascular disease risk factors.
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