The Effect Of Lamivudine On The Function Of Dendritic Cells Derivedfrom Patients With Chronic Hepatitis B Virus Infection In Vitro

Dendritic cells are crucial antigen-presenting cells responsible for initiating immunity in naive T lymphocytes and paly an important role in the induction of antiviral immune responses. One of the important reasons to result in the immune tolerance in chronic hepatitis B (CHB) patients is the impaired function of dendritic cell (DC) derived from patients with CHB which can not efficiently hand the sign of virus antigens on the immune system. One of the exactly questions to treat CHB is how to enhance the antigen presentation function of DC.Lamivudine(LAM), a nucleoside analogues, is a potent and selective inhibitor of HBV replication.. LAM specifically inhibits the hepadnaviral DNA polymerase by competing with the corresponding dNTPs for incorporation into nascent DNA and by acting as a chain terminator after incorporation . It appears to be transported into the cell via pyrimidine nucleoside transporters and is activated enzymatically by different sets of cellular enzymes . The abroad reports shown that lamivudine can up-regulate major histocompatibility complex class II expression. In China the ifluence of...