Effects Of +Gz Exposures On Astrocytes In Rat Brain

Brain function can be influenced by high sustained +Gz exposures, which is a severe threat to the pilots' safety. A few studies on the mechanisms of brain injury induced by +Gz exposures have been reported, but most of them emphasized on the aspect of the injured nerve cells; however, ignored the roles of the glial cells in brain injury, especially the roles of astrocytes. The quantity of the glial cells is approximately 10-50 times than that of the nerve cells. In the glial cells, the number of the astrocytes ranks first and the distribution of them is considerably widespread, therefore, they play a vital role in performing the majority of the functions of the glial cells. In these past years, more and more attentions have been paid to the roles of the astrocytes in brain injury. When brain injury induced by cerebral ischemia appears, swell, degeneration, apoptosis, or necrosis will appear to some extent in nerve cells. At the same time, astrocytes can be activated due to the stimulus of cerebral ischemia, and in turn there will appear a series of physiological and biochemical reactions in astrocytes, which have certain protection to nerve cells being injuried. However, the studies on activation and effects of +Gz exposures as a kind of stimulus on astrocytes were scarcely reported.The study on the mechanism of brain injury induced by +Gz exposures...