Expression Of Hypoxia Inducible Factor 1 And Vascular Endothelial Growth Factor In Laser-induced Choroidal Neovascularization In Rat

Background Choroidal neovascularization(CNV) is the formation of aberrant new vessels arising from pre-existing choroidal vasculature and extending into the subretinal space through the Bruch's membrane. The high vasopermeability of CNV can lead to exudate or hemorrhage and macular degeneration associated with severe visual loss. The pathologic study showed the sequential steps in the formation of CNV, various factors participating in the development of CNV, and vascular endothelial growth factor(VEGF) is one of the key regulators. VEGF is a highly specific mitogen for vascular endothelial cells(VEC). It can selectively stimulate EC proliferation, migration, organization into tubes, induce the anti-apoptosis protein expression and enhance vasopermeability activity. More and more people pay their attention on the role of VEGF in the formation of CNV. In the recent research, hypoxia inducible factor l(HIF-l) is the master regulator in regulate the expression of VEGF under hypoxia. It can augment the transcription of VEGF, stabilize VEGF mRNA and upregulation the expression of VEGF receptor.CNV is mainly seen in age-related macular degeneration(AMD). The deposition of...