The Features Of Ndrg2 Expression During Human Embryonic Brain Development

[Background] N-myc downstream regulated gene ( ndrg ) 2,together with ndrg1, ndrg3 and ndrg4 constitute the new ndrg family. Although ndrg family is believed to be involved in cell growth, the exact molecular and cellular function of members of this family is still unknown.Human and mouse ndrg2 that share 95% amino acid sequence identity were discovered and successfully coloned by our research group and another group respectively. Ndrg2 are located at chromosome 14qll. 2, including 16 exons and 15 introns, and its cDNA is 2024 base pair(bp) in length. Studies from our laboratory and others have shown that ndrg2 was highly expressed in many normal tissues, whereas lowly expressed in various tumor tissues and tumor cell lines . In addition , transfection ndrg2 into some tumor cell lines such as glioma cell line BT325 and Lung cancer A549 can suppress growth of these cells. Suppose that ndrg2 may play an important role in some tumor genesis and evolution. Therefore, we hypothezied that ndrg2 may be...