Proliferation And Activity Of The Delay Rectifier K～+ Channels Of The Schwann Cells Separated From Rabbit Sciatic Nerve Injured By Electrical Current Experimentally

There are two ways by which electrical current causes the tissue trauma: One is heat energy transformed from electrical energy; the other is electrical current. The latter can impair the phospholipids bilayer structure of the cell membrane, and it can even cause cell membrane break or cytolysis. It was proved that the Schwann cells still kept alive after rabbit sciatic nerve had been injured by electrical current and played a key role in the process of nerve repair and regeneration.The delay rectifier K+ channels have close connection with the proliferation of the Schwann cells. Whether electrical current experimentally exerted on the rabbit sciatic nerve, can change the activity of the delay rectifier K+ channels and consequently affect the proliferation capability of Schwann cells? There is still no answer to this question now.Our experiment aimed to observe the change of activity and function of the delay rectifier K+ channels after the Schwann cells were injured by electrical current, and to investigate the relationship between the trauma of the delay rectifier K~+ channels and the proliferation ability of the Schwann cells separated from rabbit sciatic nerve injured by electrical current.