Relation Of Stereotactic Lesions On Accumbens And Drug Addicts' Nicotine And Opiord Dependence

To date, clinical research for opiate drug dependence has focused on physiological dependence. Physiological detoxification and elimination of abstinence symptoms have been achieved through medication. However, the problem of dramatical, sometimes even compulsive, psychological craving has not been dealt with effectively. Modern research indicates that drug addiction is a serious social problem and a chronic recurrent drug-dependent brain disorder as well, which characterized by physiological and psychological dependence. Social studies have found that the main cause of relapse is psychological craving for drugs. Nucleus accumben(NAc) plays an important role. Selectively making lesion in it may cause the decrease of relapse and treat the disease. In order to provide a theoretical base for clinical experiment, we compare relapse rate of different surgery style and nicotine dependence, and then explore the effects of different lesion size on surgery.Objectives In the course of drug dependence, different part of N Ac exerts...