Prevention Of Cyclophosphamide-induced Ovarian Damage By Triptorelin In Mice

Due to improvements in cancer therapy, cure rates of cancers increased significantly. However, long-term consequences of cancer therapy and impact on quality of life are now being recognized. Chemotherapy constitutes the basis of the modern cancer treatment. ovarian damage is a common long-term consequence of chemotherapy,and the cytotoxic-induced damage is irreversible in the ovary, because the number of germ cells is limited,fixed since the fetal life, and can,t be regenerated. Ovarian damage not only puts the patients at risk for menopause-related complications just like hot flushes,night sweat,osteoporosis at a very young age, but is also associated with loss of fertility. Consequently, fertility preservation has become more important,after exposure of the female gonad to chemotherapeutic drugs. Currently there are only few available fertility preservation options, just like embryo cryopreservation,mature and immature oocyte cryopreservation,ovarian tissue cryopreservation et al, but there are many limited experience with these techniques. Currently, prior and concomitant treatment with gonadotrophin releasing hormone analogue (GnRHa) appears to be the most promising approach to prevent ovarian failure induced by cancer therapy. GnRHa is a synthetic analogue of natural GnRH, and have significant gonadal suppression through down-regulation or competitive inhibition on GnRH receptor. It has remained controversial whether and in...