Ischemic Preconditioning Study Of ProstaglandinE1 Against Spinal Cord Ischemia/reperfusion Injury Of Rats

Aim to investigate the effects of PGE1, on isehemic/reperfusion spinal cord injury. METHODS:18 rat were anesthetized with halothane and spinal cord isehemia was induced for 15 min by infrarenal aortic occlusion. Animals were randomly allocated to 3 groups: group A (n=6)and group B(n = 6) received intravenous prostaglandin El infusion (5 u g/mL/kg )at a constant rate within 10 min before aortic cross—clamping or after reperfusion respectively ; group C (n = 6) received no pharmacologlc intervention. Neurologic status was scored by the Tarlov system at 1,4, 8, 12, 24 h and 48 h after the operation The animals were sacrificed at 48h after reperfusion and the spinal cord (L5-7) was removed immediately for histopathologic study. RESULTS: All animals survived the experiment. The neurologic deficit scores at each observation time of group A and group B were significantly higher than those of group C (P< 0. 05). No difference was found between group A and B. The numbers of normal neurons at anterior spinal cord of group A and group B were more than those of group C at 48 h after reperfusion(P<0. 05). CONCLUSION :prostaglandin El, either administered before or after aortic occlusion, significantly reduces neurological injury induced by spinal cord ischemia and reperfusion...