Research Of Antitumor Effect And Expression Correlative Cytokines Of Lingqi Capsule

Objectives: To discuss the anti-tumor effect of Ling-qi capsule on mice bearing H₂₂ and they have an important influence on secreting cytokine.Further explore the mechanism of action. Methods: The model of H₂₂ tumor-bearing mice was produced and treated with high, mid and low dosage Lingqi capsule and Compound Cyclohosphamide Tablets. After giving drugs for 11 days, the inhibiting rate of tumor, thymus index, spleen index and the content of TNF-a> IL-1, IL-6 in its peripheral blood with ELISA were determined. Results: The inhibitory rate is 15.07%, 36.89% and 31.49%. Lingqi capsule obviously inhibits tumor without losing weight and influencing immune organs. Compared with the model group, the content of TNF-α IL-1 is significantly increased and IL-6 is reduced in peripheral blood. Conclusions: Lingqi capsule can obviously inhibit tumor of H-(22), enhance the life quality of mice bearing tumor. The mechanism may be:improving abnormal state of immune of the tumor mice, regulating imbalance of immune function and inhibiting the growth of tumor cells .The paper provide experimental data for theory of treating tumor in clinic.