Effect Of The Treatment With Insulin On The Orthodontic Tooth Movement Of Rats Suffering From Diabetes Mellitus

Objective: To provide experimental and theoretical evidence to test if orthodontic treatment can be carried out on diabetics by exploring the effect of diabetes mellitus on the orthodontic tooth movement under the treatment with insulin.Methods: 1 Ninety-six male SD rats whose weight range from 200 to 220 grams were chosen and randomly grouped into three groups of 32 rats, Group A, the normol group; Group B, diabetes group and Group C, Insulin treated group.Each group randomly grouped into four little groups of 8 rats. Streptozotocin (STZ) were celioinjected in rats of Group B and Group C with the amount of 50mg per kilogram. Rats in Group A were injected with the same amount of sodium citrate. Seventy-two hours later, blood was extracted from caudal vein and urine was sample before blood glucose and urinary glouse were respectively tested. Those rates whose blood glucose were above 16.8mmol/L and urinary glucose were three plus to four plus are diagnosed as diabetes. Four days after the model of diabetes mellitus was succeeded, rats in Group C began to receive subcutaneous injection of 0-4U insulin per day at their necks. The amount of injection was adjusted according to the rats'blood glucose and urinary glucose till the blood glucose...