Dynamic Observation On Brain Edema And Cyclooxygenase-2 Expression Around Ischemia In Experimental Cerebral Infarction

Objective: Intracerebral infarction (CI) is an emergent disease endangering the people's life and work because of its high mortality and serious disability. The most important pathological changes after CI are the ischemic itself and the secondary edema, which causes herniation-related death and severe neurological deficits. Although lots of improvements have been made on the prevention and treatment of CI, the mechanism of brain edema formation and secondary neuron injury are not very clear now. So the researches on CI become the focus of clinical and primary studies. Up to now, there is no one kind of mechanisms to explain the damage theorem after cerebral ischemia. Researchers consider that severeal mechenisms participate the process of cerebral infarction: metabolic block, calcium overload, cell apoptosis, the toxic action of excitatory amino acids and free radicle, the nerve damage mediated by nitrogen monoxidum, et al. In the near future, much invesidation resume that COX-2 is relate to the latter. The secondary lesion of cerebral infarction is the main cause that lead to the aggravated nerve function, and among which, brain edema is the capital pathological change ofter...