The Relationship Between The Ability Of Learning And Memory And The Proliferation Of Neural Stem Cells

Objective: To explore the relationship between the ability of learning and memory and the proliferation of the neural stem cells, and the role of astrocyte in this case. Methods: Adult male Swiss mouse were divided into two groups: Water maze training group and Control. Then the Water maze training group were divided into high ability group(HLM), ordinary ability group(OLM) and low ability group(LLM) according to the performance in water maze training. At the final three days of the maze training ,all animals received three injection of BrdU (50 mg/kg i.p, every 4 h for 12 h) per day. At either 1, 7, 14 days after training, the neurogenesis was detected. Results: 1. the mice of Water maze training group were divided into three groups successfully. 2. Immunohistochemistry:⑴.At 1day after training, the number of BrdU+ cells in HLM and OLM was more than control notably in dentate gyrus (P<0.01,P<0.05), but threre was not a difference between LLM and control (P<0.01).⑵.At 7day after training, the number of BrdU+ cells in water maze training group was more than control significantly in dentate gyrus (P<0.05,P<0.01), and it was same between HLM and other groups(P<0.05,P<0.01).⑶.At 14day after training, there was a obvious discrepancy among four groups in the number of BrdU+ cells in dentate gyrus(P<0.01),and it was the HLM who had the most number of BrdU+ cells in dentate gyrus ,then was OLM, LLM and control.⑷. At either 1, 7, 14 days after training, there was not difference in the number of BrdU+ cells in SVZ among groups (P>0.05).⑸. At either 1, 7, 14 days after training, there was not difference in the number of GFAP+ cells and in the gray of GFAP+ cells among groups in hippocampus (P>0.05). Conclusion: There was a positive correlation between the ability of learning and memory and...