The Changes Of Cardiac Enzymes And The Effectiveness Of Vasopressin For Cardiopulmonary Resuscitation In An Asphyxia Rabbit Model

Objective: cardiac arrest (CA) is an emergent incident and needs to be treated with cardiopulmonary resuscitation (CPR) immediately. Although CPR has been performed for many years, the rate of successful resuscitation is low especially in the severe bradyasystolic arrest. Then people thought it is necessary to copy the bradyasystolic arrest model and investigate its pathophysiologic mechanism. Epinephrine has been the preferred adrenergic amine in CPR for long time, but its effectiveness is still far from satisfaction. Searching more effective medicines has been the highlight. Some scholars found that plasma vasopressin concentrations are higher in resuscitated patients than in nonresuscitated ones during CPR. The result interested many researers. They try to apply vasopressin during CPR and find vasopressin is more effective in the ventricular fibrillation model than epinephrine. But the efficacy of vasopressin during CPR remains controversy in asphyxia cardiac arrest model. So we choice the rabbit as experimental animal to copy the bradyasys- tolic arrest model through clamping its trachea and to investigate the relationship between the changes of cardiac enzymes and other biochemical markers and the result of CPR, moreover, to investigate if vasopressin has an advantage of epinephrine for CPR in this model.Methods:1. After 15 rabbits were anesthetized, a cannula was inserted through a tracheostomy and the polyethylene catheters were advanced into the...