| Objection: To investigate the impact of hepatic ischemia-reperfusion on kidney of rats. Methods: A model of liver I/R injury was established by imitation. Forty-eight healthy Wister rats were randomly divided into 6 groups as following (n=8): the control group(CTL, the group of sham operation), simply ischemia 30min without reperfusion (I group), reperfusion following ischemia 30min(I/R group), 1 hour reperfusion following ischemia 30min (I/Rlh), 2 hours reperfusion following ischemia 30min (I/R2h) and 4 hours reperfusion following ischemia 30min (I/R4h). In each group the rats were killed to obtain samples of kidney at the specified time points. The contents of GTP, AKP, γ-GT, BUN, Cr in blood and MDA in kidney were observed in each group. The content of angiotonin II (Ang II), aldosterone(AId) and endothelin (ET) in plasma and kidney were measured by radioimmunity. Results: Hepatic ischemia-reperfusion resulted in significant kidney injures. With the extension of ischemia- reperfusion, compare with CTL, BUN and Cr in blood were increased significantly in I group (P<0.05), γ-GT were increased in I/R group (P<0.05).The content of MDA in kidney increased in the 2h, 4h reperfusion group were significantly higher than CTL group (P<0.05). The Na+-K+ ATPase Ca2+ATPase gradually decreased in I/R1h, I/R2h and I/R 4h group, compared with CTL, difference was statistically significant (P<0.05). Compared with CTL,...
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