| Objective: 1.To compare short-term clinical efficacy of iodine-131 treatment for Graves hyperthyroidism between fixed dose and calculated dose methods.2.To evaluate the correlation of thyroid volume measurement between ultrasound and palpation.Methods: 123 Patients (13-66 years, mean age 36.92 years) with Graves hyperthyroidism were randomly allocate to six treatment groups: low-fixed (5mCi), medium-fixed (7.5mCi), high-fixed (10mCi), low-calculated (60uCi/g of thyroid tissue adjusted for 24h radioiodine uptake), medium-calculated (90uCi/g of thyroid tissue adjusted for 24h radioiodine uptake), high-calculated (120uCi/g of thyroid tissue for 24h radioiodine uptake. Follow-up was done 3, 6 and 9 months post therapy, serum free T3, T4 and TSH were measured and following clinical outcome was monitored: persistent hyperthyroidism , hypothyroidism, and euthyroidism. Statistical analysis was performed with SPSS software (version 11.5). P<0.05 was taken as indicating a statistically significant effect.Results: 1. The occurrence of hypothyroidism 9 months after iodine-131 therapy in fixed-dose group and calculated-dose group was 27.4% and 26.2%...
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