Expression Of Bag-1,bcl-2 And Bax And It's Significance In Non-small Cell Lung Cancer And The Correlation With Multidrug Resistance

Background and objective It has been proved that the apoptotic suppression may plays an important role in the oncogenesis and development of malignant tumor. Bag-1 is an anti-apoptotic gene. The whole name is bcl-2 associated athanogene-1. The encoded protein of bag-1 gene has not homogenesis sequence with bcl-2 family. It is a new bcl-2 associated protein not belonged to bcl-2 family. The main function of bag-1 protein is the suppression to cell apoptosis combined with bcl-2 protein or by itself. Bcl-2 is apoptotic suppressing gene. The main function is suppressing cell apoptosis and taking part in the tumorgenesis. Bax belongs to the bcl-2 family. It has 40% homogeneity with bcl-2, but its function is promoting cell apoptosis. The expression level of bcl-2 and bax and the ratio of them (bax/bcl-2) plays animportant role in deciding whether the cells can survive after accepting the apoptotic signal. It has been proved that the bag-1 and bcl-2 gene have not only related to the tumorgenesis, but also have relationship with the multi-drug resistance. Therefore, the tumor with high expression of bag-1 and/or bcl-2 is drug-resistant cell line. The objective of this study is to investigate the expression of bag-1, bcl-2 and bax in non-small cell lung cancer, and to study the relationship between their expressions and the clinical-pathological characteristics, and also to evaluate their correlation with multi-drug resistance.