A Preliminary Investigation On NSCLP Plasma Using NMR-based Metabonomics

Objective: The congenital cleft of lip and palate is one of the common developmental deformities of oral and maxillofacial region. The incidence rate of Neonatal cleft of lip and palate is different among race, area and nations, it' s estimated incidence rate is about 1/600 all over the world. The incidence rate of cleft of lip and palate in our country is high, Prevention and treatment of cleft of lip and palate plays first role over other congenital malformations. The patient with cleft of lip and palate not only causes facial malformation, but also affects child's speech and acoustic sensibility, even psychologic obstacle. It derives from an embryopathy with consequently failure or the nasal process and/or palatal shelves fusion. It can seriously affect the quality of life also and becomes the urgent problem to solve up to now. At present extensive and receptive categorization is divided cleft of lip and palate into NSCLP and SCLP, NSCLP included CLP and CPO. The NSCLP is the most frequent of congenital malformation and occupies 70% in integral schistoprosopia. The etiological factor of SCLP is identified and concerned with autochthonous and special assortment of genes while most of NSCLP is CLP, which etiological...