Systematic Review Of The Performance Of TCu380A With Other Common IUDs

Objective To evaluate the effectiveness of TCu380AIUD with other commonIUDs. Methods CBMDISC (1979-2005), Wanfang(1994-2005), CNKI(1974-2005), CMCC(1979-2005), CMAC(1994-2005), EMBASE (1974-2004), MEDLINE (1974-2005), WHO/RHL(2004~2005), The Cochrane Library (Issue 4, 2004), SCI(1985~2005), POPLINE (1966—2003) and 9 related journals were searched for randomized controlled trails(RCTs) on the comparison between TCu380AIUD and other common IUDs. The quality of included trials was critically appraised. RevMan4.2.7 software was used for statistical analysis. Results Fifteen published studies with 20, 417 participants were included. The results of meta-analysis were expressed with OR (cumulative expulsion rate, cumulative pregnancy rate, cumulative rate of removing for medical reasons) and 95% CI. Compared with TCu380A, TCu220C resulted in lower cumulative expulsion rate at 0.5, 1 years of follow-up[with the OR 0.36 (0.18—0.70) ; 0.44 (0.31—0.62), respectively], higher cumulative pregnancy rate in ten year of follow-up [1.22 (1.04—1.43) ] , lower cumulative rate of removing for medical reasons at 0.5 year follow-up [0.59 (0.36—0.97) ]; MLCu375 resulted in higher cumulative expulsion rate at 1 year of follow-up[2.17 (1.29—3.67) ], higher cumulative pregnancy rate at 1, 2 year of follow-up[1.72 (1.18—2.50); 1.28 (1.02—1.60)]; UCD300 resulted in lower cumulative expulsion rate at five year of follow-up[0.38 (0.27.—0.56) ]; Medicated Gamma 380IUD resulted in lower cumulative rate of removing for medical reasons at 1 year of follow-up[0.31 (0.14-0.70) ].