Association Between Polymorphism Of GSTP1 And Susceptibility To Childhood Asthma

Objective To investigate the polymorphism of GSTP1 gene and the association between polymorphism of GSTP1 and susceptibility to childhood asthma. Methods The distribute frequency of Ile105/Ile105, Ile105/Val105 and Val105/Val105 genotype in GSTP1 of 51 children with asthma and 40 normal children was studied with PCR-RFLP . Results In our research the frequencies of Ile/Ile, Ile/Val and Val/Val genotype were 66.7%, 27.4% and 5.9% respectively, the frequencies of Ile, Val allele were 80.4% and 19.6% in the asthma group. But the frequencies of Ile/Ile, Ile/Val and Val/Val genotype were 90%, 7.5% and 2.5% respectively, the frequencies of Ile, Val allele were 93.8%,6.2% in the control group. The frequencies Ile/Val, Val/Val genotype and Val allele in the asthma group were more than in the control group. A significant difference was found in the frequency distribution of GSTP1 genotypes between two groups (x~2=6.947, P<0.05). In the patient...