The Study On Treatment Of Malignant Hydrothorax And Promote The Fibrosis Of Pleural Of Kang'ai Xiaoshui Cream

Objective: The Kang'ai Xiaoshui Cream is the use of the external treatment of Chinese drugs in curing malignant pleural effusion. Study has confirmed that the Kang'ai Xiaoshui Cream can percutaneous absorption, can improve cellular immunity and inhabit the proliferation of human lung cancer cell lines in vitro. Clinical trail had observed that the Kang'ai Xiaoshui Cream can promote pleura adhesion .On the foundation of the past study , this topic will observe the external treatment of the Kang'ai Xiaoshui Cream in curing malignancy pleural effusion through clinical and empirical study, and find out the dependability between the curative effect of pleural fluid and pleura adhesion , then will have a further investigation about the mechanism of the Kang'ai Xiaoshui Cream in improving fibrosis of pleura. Method:In clinical study, randomly separating 43 patients with PS>2 and with carcinoma of lung or breast and affiliated malignancy pleural effusion into the group of experiment (treat by the Kang'ai Xiaoshui Cream on external treating) and group of contrast (treated by IL-2 in thoracic cavity dabbing) . Observing curative effect about the pleural fluid, the pleura adhesion , the improvement of clinical symptom , the quality of life, the adverse effect and degree , and we adopted ELISA to detect the level of PCⅢ in pleural fluid before and after curing.In the experiment study, we adopted Wister rat which were inoculated walker-256 tumor strain in thoracic cavity dabbing as the contrast group . Observing the amount of pleural fluid and the alteration of pleura histology alter and the level of MCP-1 in pleural fluid and BLAF. Result: The effective rate of pleural fluid curing, the curing group is 63.64%, the contrast group is 57.14%, the two sets have not distinct difference (P>0.05). After one month curing, the masccline rate of pleura adhesion to the curing group is obvious than contrast group (P<0.05). The effective rate of the patients whose pleura adhesion are masccline is 84.62%. Obviously higher than the negative ones (50%) . The improvement rate of the chest complaint ,chest distress ,oliguresis is so patency than contrast group, about the improvement of quality of life, the curing group is better than the contrast group. Moreover , the incidence of adverse effect of anticancer and water-excluding paste is low , the safety is II degree, better than the contrast group: After one month curing, the level of PCIII is (818.28 ±60.55)ug/ml , (443.93 ±277.20)ug/ml respectively (P<0.05).