Studies On The Analysics Methods And Pharmacokinetics Of Cefixime

Cefixime is one cephalosporin of the third generation. Three HPLC methods were developed to determine cefixime content in capsules and its concentration in human plasma and urine for the quality contral of the formulation and pharmacokinetics study.1 Determination of Cefixime in capsule by HPLCAn HPLC method was developed to determine the content of cefixime in capsules. The separation was carried out on a Hypersil ODS C₁₈, with 10mmol/L tetrabutylammonium hydroxide (pH7.0)-acetonitrile(75:25,v/v) as mobiles phase at a flow-rate of 1.0ml/min. The detection wavelength was 288nm. The standard curve was linear in the concentration range of 72.5-435.0μg/ml. The average recovery was 99.5% and the RSD was 1.1%.2 Determination of Cefixime in human plasma by high-performance liquid chromatographyA selective high-performance liquid chromatographic method was developed for the determination of cefixime levels in human plasma. Cefixime was separated from the endogenous interfering substance on a Thermo Hypersil-Keystone ODS-2 column, using 0.01mol/L phosphate...