Design And Synthesis Of Derivatives Of γ-DDB

γ-DDB has been well known as an effective agent for liver protect. It has a high biologic activity and is deserved for research as a lead compound. It can decrease hepatic damage and hepatocytes necrosis induced by chemical substance such as carbon tetrachloride, D-galactosamin or thioacetamide, lower the level of syrum glutamic-pyrumic transaminase(GPT) and glutamic-oxalacetic transaminase (GOT), relieve the symptom of intoxicant hepatitis caused by chemotherapic agents such as Fluorouracil, Methotrexate. γ-DDB has no mutagenicity or malformationity and low toxicity.But it has a bad solubility and a low bioavailability Amino-acid has the effect of nutrition provision and some has the effect of hepatic protection. Considering combination principle, this curriculum designed to add amino-acid with the Y -DDB and through these medicine we hope to attain some double-functional compounds;and improve the bioavailability considering transfer mechanism and improve the drug effect.In this paper 19 derivatives of γ-DDB were synthesized, 17 of them were new compounds. Their structures were confirmed by ~1H-NMR and MS. The pharmacological test showed that some of these compounds could lower the level of syrum GPT .