Study On The Cilostazol Fast Buccal Disintegrating Tablet

Cilostazol is a kind of platelet aggregation inhibitors, and is often administrated orally in the treatment of stable angina cruris. Its therapeutic effects were certain and its side effects and toxicities could be neglected. To make it convenient for the patients to take it, we studied the preparation of Cilostazol fast buccal disintegration tablet in this article.Firstly, the physico-chemistry properties such as dissolubility, apparent oil/water distribution ratio and so on were investigated for the following work of prescription design and pharmaceutical research.Cilostazol is bitter and slightly soluble in water. To cover up its disagreeable taste and promote its solubility, the condition of utilizing microballoons silicagel to absorb the medicine was optimized in accordance with the results of the single factor investigation. And the silicagel's capacity of absorbing the drug was increased by using in the technology of solution lamination. The disagreeable taste of the drug is well masked when the particals' weight of the Cilostazol microcapsule which used aqueous dispersion of SURELEASE as its coating materials is increased by 20%.The manitol, cellulose microcrystallisate and crospolyvinylpyrrolidone were chosen as the main adjuvants of the fast buccal disintegrating tablet after the investigating of the solubility and the compress formability of several kinds of adjuvants. And the optimal proportion of the three adjuvants was determined through orthogonal experiments. Finally, the fast buccal disintegrating tablet was prepared using direct compression method whose procedure was simple and the cost was low. It was confirmed by the result of the solution rate experiment in vitro that the solution velocity of fast buccal disintegration tablet was faster than common tablets.The preliminary research of the quality of this preparation was studied which provided basic...