Injury Of Cardiac Structure Proteins And Its Significance Of Forensic Medicine In Viral Myocarditis

Viral myocarditis (VM) is the viral infection desease,which is characterized by myocardial inflammation. Some researches showed that the incidence increased gradually in recent years. Sudden death is the most severe complication of VM which is found frequently in forensic pathological autopsy. The Dallas standard which is used for pathological diagnosis of VM has its defect to distinguish borderline VM and no VM.Moreover, we often find single or foci lymphocyte infiltrates in some normal myocardial interstitium. So it is very difficult to make a definitive diagnosis in some cases of sudden death that have little myocardial changes and inflammation under light microscope. And it is also difficult to give pathological diagnosis and to find the cause of death in those cases. Therefore, we need a effective method to detect myocardial damage and to identify the cause of death. Some foreign investigations demonstrated that some structure proteins of cadiocyte could reduce or deplete when myocardial cells are injured by ischemia,hypoxia and inflammation. Some internal researchers also found the reduction and depletion of varied myocardial structure proteins in the tissues which were from forensic pathological autopsy of VM and myocarditis animal models. In addition, Burke pointed that immunohistochemistry...