The Study Of Adiponectin Expression And Its Relationship With TNF-[alpha]

Background and Objective: The metabolic syndrome (MS) is a constellation of visceral fat obesity, impaired glucose metabolism, dyslipidemia, and blood pressure elevation, which all independently increase risk of cardiovascular diseases (CVD), especially the risk of diseases for atherosclerosis (AS), such as ischemic heart disease and cerebral stroke. Insulin resistance(IR) has been implicated as the key factor that links MS and CVD in resent years. Now it is considered that visceral adipose tissue plays the most important role for it. The adipose tissue is an important endocrine organ that secretes many biologically active substances, which are collectively termed adipocytokines. Evidence shows that dysregulated production of proinflammatory and antiinflammatory adipocytokines seen in visceral adipose tissue is associated with IR, and that inflammatory changes within the adipose tissue may critically contribute to the development of many aspects of CVD. adiponectin is one of the most important adipocytokines, which ,secreted only from adipocytes, has the property of antiinflammatory and cardiovascular protection. It is found that the adipocytokine is...