Renal Dysfunction Following Pediatric Cardiopulmonary Bypass And Its Risk Factors Study

Cardiopulmonary bypass (CPB) is the precondition to proceed open heart operation for children with congenital heart disease. As one of the most important organs, kidney impairment is one of the most popular complications and will have poor prognosis and high mortality as long as developed to acute renal failure. Up to now, many published articles have studied renal insufficiency in adult during CPB by detecting blood urea nitrogen, creatinine and uric acid . Urine N-acetyl-β-D-glucosaminidase and blood Cystatin C have been proved to be more sensitive and specific markers reflecting renal function. The unification of these two markers with commonly used ones is unclear. Few study tried to probe renal dysfunction by detecting N-acetyl-β-D-glucosaminidase (NAG) and Cystatin C (CysC),which are more sensitive and specific markers reflecting renal function. Here we try to study the renal dysfunction following pediatric cardiopulmonary bypass by detecting more sensitive and specific markers, find the risk factors and hence to propose more effective prevention measure aimed to reduce renal complication.