Biomechanical Properties Of Vaginal Tissue In Pelvic Floor Dysfunctional Women

【Objective】To explore the relationship between biomechanical properties and the occurrence of pelvic floor dysfunction (PFD) though analysis on biomechanical properties of vaginal tissue, and expression of estrogen receptor (ER).【Methods】Transvaginal biopsies were obtained from the vaginal tissue in SUI, POP ,SUI+POPand in comparable control. Eighty-five women participated in the study. They were divided into 8 groups as follows: 12 premenopausal patients with SUI (group 1), 9 premenopausal patients with POP(group 2), 11 premenopausal patients with either SUI or POP(group 3),14 premenopausal patients with neither SUI nor POP(group 4),12 postmenopausal patients with SUI (group 5), 12 postmenopausal patients with POP (group 6), 7 premenopausal patients with either SUI or POP(group 7),and 8 postmenopausal patients with neither SUI nor POP(group 8). Tissue specimens were biomechanically assessed by a purposed-built tissue puller system and stress-strain curves were digitally recorded. The histological structures in vaginal tissues were examined with routine HE staining. ER in vaginal tissue were evaluated by immunohistochemical staining.【Results】The Young's modulus, Poisson's ratio, maximum elongation, maximum fracture,shear modulus of vaginal tissue were 9.45±0.70, 0.43±0.02, 1.50±0.02, 0.60±0.02,3.30±0.22 in premenopausal POP group;12.10...