Association Of Tumor Necrosis Factor Receptor (TNFR â…¡) Polymorphism With Susceptibility To Coronary Heart Disease

Background and ObjectivesThe rate of Coronary heart disease (CHD) has step up obviously in our nation and the whole global. Genetic predisposition and inflammation are two important factors in the development of atherosclerosis and coronary artery disease (CAD). Tumor necrosis factor alpha (TNF-α) is a significant Proinflammatory cytokine which exerts its effect via its receptors. Tumor Neerosis Factor Receptor (TNFR II) gene is localized on 1p36, which there is mutation from ATG to AGG for gene 196, resulting in a displacement of methonine(M) by a lysine(R). Sankar VH ' research found this polymorphism is associated with susceptibility to CHD.But ALLEN RA arrive at contrary consequence. This is possible because different race has different genotype. There have been no report which is about the association of TNFR II Polymorphism With Susceptibility To coronary heart disease in our country. In this study we have tested the role of TNFR II polymorphism in predisposition to CAD. our objective is to discover the hazard crowd of CHD through screening risk factor of inflammatory factors, and to promote earlier period precaution and give personality treat. The objective of this research explain as follow:1. to applicate a method of polymerase chain reaction-restriction...