The Change Of Serum TNF-α,VEGF And Its Role In Type 2 Diabetic Retinopathy

Background and objectiveDiabetes mellitus, which is characterized by chronic hyperglycemia, is a kind of clinical syndrome caused by both hereditary and environmental factors. Its morbidity is increasing year by year, bringing the patients lower life quality and shorter lifetime.Diabetic retinopathy (DR) is one of the most common and severe microvascular complications of diabetic mellitus, moreover, it can lead to blindness directly. The exact mechanism of DR is not quite clear. Recently, it is believed that DR results from the cooperation of multiple factors, in which some cytokines appear to play an important role.The aim of this study is to investigate the relationship between plasma tumor necrosis factor alpha (TNF-α), vascular endothelial growth factor (VEGF) and diabetic retinopathy in type 2 diabetes mellitus.Methods65 cases, diagnosed of type 2 diabetes mellitus definitely according to 1999 World Health Organization Criteria of diabetes mellitus, were recruited into the study. They were divided into three groups: NDR group (22 cases): T2DM patients without diabetic retinopathy; BDR group (22 cases): T2DM patients with background diabetic retinopathy; PDR group (21 cases): T2DM patients with proliferative diabetic retinopathy. All of them must not afflicted by the subsequent diseases presented in the following: infection disease within half a month, malignancy, chronic liver malfunction, chronic renal failure, autoimmune diseases, etc. Another 19 healthy people were chosen as normal control (group C). There is a match of sex and age among four groups. Serum TNF-α and VEGF were measured by enzyme-linked...