Study On The Correlation Between Spiral CT Features, The Expression Of Cath-D And UPA In Esophageal Carcinoma

Background and purpose:Esophageal carcinoma is one of the most common malignant tumors in digestive tract,which has strong ability of invasion ,and the infiltration, metastasis of tumor is the main reason of the death ,also is the reason of the treatment failure.Investigating the relationship between outwards appearance and molecular mechanism in the development and metastasis of esophageal carcinoma ,therefore,is significant to radiology,pathology and molecular biology.As an effective technic in the examination of the esophageal carcinoma, contrast spiral CT can display the invasion and metastasis of tumor distinctly.The infiltrate and metastasis of tumor is correlated with the degradation of extracellular matrix(ECM) and basement membrane components.Recently,it was discovered that cathepsin D(Cath-D) and urokinase-type plasminogen activator(uPA) can degradate the ECM and basement membrane components,and play an important role in the infiltration and metastasis of tumor.As the members of proteolytic enzyme , Cath-D and uPA can have effect on many kinds of basement membrane components ,and degradate the ECM and basement membrane components,also destroy the barrier shield of parasitifer stroma.The high...