Study Of The Inhibiting Effects Of Cyclosporine(CsA) On Human Retinal Pigment Epitheliuml Cells Cultured In Vitro

Proliferative vitreoretinopathy (PVR) is identified with a disease which often happens after rhegmatogenous retinal detachment, retinal reattachment surgery and ocular trauma, and appears proliferation of cellular membranes within the vitreous cavity and on both retinal surfaces. It causes not only the secondary detachment of retina,but also causes to vision lose.The mechanism of PVR was unknown, but its basic pathogenesis has been realized. A great deal of studies showed there were 3 procedures in PVR formation: inflammation, proliferation and scaring. PVR is character of excessive proliferation of RPE cells ,which can be seen almost in all PVR membrane . RPE cells, collagenocyte, fibroblasts can migrate from retinal pigment epithelium layer to the vitreous cavity and proliferate and contract, finally cause to retinal detachment. So RPE cells play an important role in PVR.Despite the improvement of surgical reattachment rates with vitrectomy which can relieve the retinal traction and make it reattachment, preretinal membrane often need to be peeled, and the modern vitrectomy surgery was unable to prevent the cells proliferation and PVR membrane formation. So there was certain postoperative relapse rate. For increasing the surgical success rate, recently many studies have tried to use medicine to inhibit cellar proliferation .